Family members often feel exhausted because of the time and energy spend on issues related to the illness.  There is little energy left to invest in other potentially satisfying relationships or rewarding activities.  Increased tension leads to risk of marital dissolution and stress-related physical symptoms.  It is not uncommon to hear worn out spouses desperately stating, half joking, half seriously, "I', the one who will be in the hospital next."

Siblings may experience jealousy if too much attention is devoted to the ill member and not enough to themselves.  To deal with feelings of resentment and guilt, siblings may spend more time away from the family.  When the ill member is a parent who cannot meet the emotional needs of his or her spouse, a child may assume the role of confidante with the well parent and may sacrifice some of his or her own personal development as an independent individual.

In general, the emotional welfare of all family members is at risk because of ongoing stress.  It is important for the family to be aware of these risks and to take appropriate measures (for instance, getting support from outside sources) in order to minimize the risks.